How to Check for NP-C

The following tools and resources aim to support healthcare professionals to understand more about NP-C, the key symptoms of NP-C and how to check for eye movement abnormalities so suspected patients can be referred on to a specialist centre for diagnostic testing.

How to check for eye movement abnormalities

Vertical supranuclear gaze palsy (VSGP) is a typical symptom of NP-C and is present in virtually all patients with NP-C. It often goes undetected, despite it being simple to detect by testing for impairment of voluntary saccades, which is an early sign of NP-C.1,2 All healthcare professional specialties that might see a patient with NP-C and see one or more of the symptoms listed in the Key symptoms of NP-C table should check for eye movement abnormalities. For additional support on how to perform an eye examination please visit for step-by-step video guidance.

Two step process to test for VSGP:

  1. To assess the smooth pursuit, patients should be tested for their ability to follow an object
  2. To assess the vertical saccades the physicians will ask the patient to spontaneously move their gaze up and down without following an object (ask to look between two points fixed by the upper part of their head and at chest level)

How to check for VSGP – click for full size– Image

Educational slide set for healthcare professionals

This slide set aims to support healthcare professionals to recognise the signs and symptoms of NP-C. Feel free to download this slide set for your own information and to present to other healthcare professionals at appropriate meetings or confer

Download the slideset– Presentation

Tools to aid suspicion of NP-C

The following tools can support healthcare professionals to suspect NP-C by linking key presenting symptoms together.

  • NP-C Suspicion Index
    A simple screening tool that has been developed in collaboration with a group of international experts in the field of NP-C. It aims to enhance the detection of NP-C among patients suspected of having the condition in order to establish an earlier diagnosis.1,3
  • FindZebra –
    A specialised search engine supporting healthcare professionals to understand possible diagnoses for difficult patient cases by typing in the symptoms that a patient presents with